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Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
Ma, Zhenkun; He, Shijie; Yuan, Ying; Zhuang, Zhijun; Liu, Yu; Wang, Huan; Chen, Jing; Xu, Xiangyi; Ding, Charles; Molodtsov, Vadim; Lin, Wei; Robertson, Gregory T; Weiss, William J; Pulse, Mark; Nguyen, Phung; Duncan, Leonard; Doyle, Timothy; Ebright, Richard H; Lynch, Anthony Simon.
Affiliation
  • Ma Z; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
  • He S; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
  • Yuan Y; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
  • Zhuang Z; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
  • Liu Y; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
  • Wang H; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
  • Chen J; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
  • Xu X; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
  • Ding C; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
  • Molodtsov V; Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.
  • Lin W; Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.
  • Robertson GT; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, 80523-1682, United States.
  • Weiss WJ; HSC College of Pharmacy, University of North Texas, Fort Worth, Texas 76107, United States.
  • Pulse M; HSC College of Pharmacy, University of North Texas, Fort Worth, Texas 76107, United States.
  • Nguyen P; HSC College of Pharmacy, University of North Texas, Fort Worth, Texas 76107, United States.
  • Duncan L; JMI Laboratories, North Liberty, Iowa 52317, United States.
  • Doyle T; JMI Laboratories, North Liberty, Iowa 52317, United States.
  • Ebright RH; Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.
  • Lynch AS; TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China.
J Med Chem ; 65(6): 4481-4495, 2022 03 24.
Article in En | MEDLINE | ID: mdl-35175750
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifamycins / Helicobacter pylori / Helicobacter Infections / Nitroimidazoles Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifamycins / Helicobacter pylori / Helicobacter Infections / Nitroimidazoles Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication: