The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway.
Proc Natl Acad Sci U S A
; 119(9)2022 03 01.
Article
in En
| MEDLINE
| ID: mdl-35197279
ABSTRACT
Axin is one of two essential scaffolds in the canonical Wnt pathway that converts signals at the plasma membrane to signals inhibiting the degradation of ß-catenin, leading to its accumulation and specific gene activation. In vertebrates, there are two forms of Axin, Axin1 and Axin2, which are similar at the protein level and genetically redundant. We show here that differential regulation of the two genes on the transcriptional and proteostatic level confers differential responsiveness that can be used in tissue-specific regulation. Such subtle features may distinguish other redundant gene pairs that are commonly found in vertebrates through gene knockout experiments.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Axin Protein
/
Wnt Signaling Pathway
Limits:
Humans
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2022
Document type:
Article