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Toxicity assessments and transcriptional effects of monofunctionalized Pt(II) complex under dark and light irradiation condition in Caenorhabditis elegans.
Chong, Hui; Fang, Siyu; Yang, Di; Tan, Chuan; Wei, Junjie; Chang, Shu-Han; Fan, Hongying; Yao, Hang; Qin, Aijian; Shao, Hongxia; Zhang, Yuefei; Leng, Junling; Su, Dawei; Wang, Chengyin; Li, Hualing.
Affiliation
  • Chong H; College of Chemistry and Chemical Engineering, Yangzhou University, 180 Si-Wang-Ting Road, 225002, Yangzhou, Jiangsu Province, China. Electronic address: chonghui@yzu.edu.cn.
  • Fang S; College of Chemistry and Chemical Engineering, Yangzhou University, 180 Si-Wang-Ting Road, 225002, Yangzhou, Jiangsu Province, China.
  • Yang D; Institute of Translational Medicine, Medical College, Yangzhou University, City of Yangzhou, Jiangsu Province 225001, China.
  • Tan C; College of Chemistry and Chemical Engineering, Yangzhou University, 180 Si-Wang-Ting Road, 225002, Yangzhou, Jiangsu Province, China.
  • Wei J; Institute of Translational Medicine, Medical College, Yangzhou University, City of Yangzhou, Jiangsu Province 225001, China.
  • Chang SH; Department of Acupuncture and Moxibustion, Yangzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, City of Yangzhou, Jiangsu Province 225012, China.
  • Fan H; Testing Centre of Yangzhou University, City of Yangzhou, Jiangsu Province 225009, China.
  • Yao H; College of Chemistry and Chemical Engineering, Yangzhou University, 180 Si-Wang-Ting Road, 225002, Yangzhou, Jiangsu Province, China.
  • Qin A; Ministry of Education Key Lab for Avian Preventive Medicine, Key Laboratory of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, City of Yangzhou, Jiangsu Province 225009, China.
  • Shao H; Ministry of Education Key Lab for Avian Preventive Medicine, Key Laboratory of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, City of Yangzhou, Jiangsu Province 225009, China.
  • Zhang Y; Department of Emergency, Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu, China.
  • Leng J; Department of Emergency, Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu, China.
  • Su D; Center for Clean Energy Technology, School of Mathematical and Physical Science, Faculty of Science, University of Technology Sydney, NSW 2000, Australia. Electronic address: Dawei.su@uts.edu.cn.
  • Wang C; College of Chemistry and Chemical Engineering, Yangzhou University, 180 Si-Wang-Ting Road, 225002, Yangzhou, Jiangsu Province, China. Electronic address: wangcy@yzu.edu.cn.
  • Li H; Institute of Translational Medicine, Medical College, Yangzhou University, City of Yangzhou, Jiangsu Province 225001, China; Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, City of Yangzhou, Jiangsu P
J Inorg Biochem ; 230: 111720, 2022 05.
Article in En | MEDLINE | ID: mdl-35221123
ABSTRACT
In vivo toxicity of aromatic ring (BODIPY, 1,3,5,7,8-pentamethyl dipyrrin borondifluoride) attached monofunctional Pt(II) complexes mCBP {[cis-Pt(NH3)2Cl] 8-(para-pyridine-methylene),1,3,5,7-tetramethyl dipyrrin borondifluoride}+ Nitrate- and dCBP {[cis-Pt(NH3)2Cl]28-(1,3-pyrimidine-5-methylene),1,3,5,7-tetramethyl dipyrrin borondifluoride}2+ diNitrate2- were tested in Caenorhabditis elegans (C. elegans). dCBP showed promising reactive oxygen ROS (reactive oxygen species) generating capability. This complex resulted reduction of lifespan, body length and egg laying rate under dark and light irradiation in both N2 (wild-type, cisplatin resistant) and ok938 (asna-1, cisplatin sensitive) C. elegans. Expressional change of several key cancer related pathway (JNK (c-Jun N-terminal kinase) and Wnt/ß-catenin (Wingless/Integrated/ß-catenin)) related genes (for instance, jnk-1, wrm-1 and gst-4) were confirmed by RNA sequencing experiments. These transcriptional alternations could explain physiological parameters change in nematode and partially revealed how both Pt(II) based complexes influence cancer related pathways. Furthermore, these associated genes exhibited the function of apoptosis, reduced chemoresistance of cancer cells and most of those expressional changes were linked to extended survival of cancer patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platinum / Caenorhabditis elegans / Caenorhabditis elegans Proteins Limits: Animals / Humans Language: En Journal: J Inorg Biochem Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platinum / Caenorhabditis elegans / Caenorhabditis elegans Proteins Limits: Animals / Humans Language: En Journal: J Inorg Biochem Year: 2022 Document type: Article