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Preclinical evaluation of a mannose-labeled magnetic tracer for enhanced sentinel lymph node retention in the head and neck.
Krishnan, Giri; Cousins, Aidan; Pham, Nguyen; Milanova, Valentina; Nelson, Melanie; Krishnan, Shridhar; Shetty, Anil; van den Berg, Nynke; Rosenthal, Eben; Krishnan, Suren; Wormald, Peter-John; Foreman, Andrew; Thierry, Benjamin.
Affiliation
  • Krishnan G; The Department of Otolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, SA, Australia.
  • Cousins A; Future Industries Institute, University of South Australia, Mawson Lakes, SA, Australia. Electronic address: aidan.cousins@unisa.edu.au.
  • Pham N; School of Chemistry, University of New South Wales, Sydney, NSW, Australia.
  • Milanova V; Future Industries Institute, University of South Australia, Mawson Lakes, SA, Australia.
  • Nelson M; Ferronova Pty Ltd., Mawson Lakes, SA, Australia.
  • Krishnan S; The Department of Otolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, SA, Australia.
  • Shetty A; Ferronova Pty Ltd., Mawson Lakes, SA, Australia.
  • van den Berg N; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Rosenthal E; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Krishnan S; The Department of Otolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, SA, Australia.
  • Wormald PJ; The Department of Otolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, SA, Australia.
  • Foreman A; The Department of Otolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, SA, Australia.
  • Thierry B; Future Industries Institute, University of South Australia, Mawson Lakes, SA, Australia. Electronic address: benjamin.thierry@unisa.edu.au.
Nanomedicine ; 42: 102546, 2022 06.
Article in En | MEDLINE | ID: mdl-35278683
ABSTRACT
Sentinel lymph node biopsy in cancers of the head and neck offers demonstrated clinical and diagnostic value, but adoption is limited by concerns about the detrimental consequence to survival of false negative results in a highly curable setting. The aim of this study was to demonstrate potential to overcome this via application of a novel mannose-labeled magnetic iron oxide tracer. In a large animal model, preoperative imaging and intraoperative magnetometer detection were used to identify magnetic lymph nodes. Iron quantification mapped the distribution of tracer within lymphatic levels. Over a 4-week test period, uptake of magnetic tracer in lymph nodes increased in a linear-like fashion, with a substantial percentage of accumulated iron (83%) being retained in the sentinel node. This result indicates a high affinity of mannose-labeled particles to the sentinel node, while providing a means for the magnetometer probe to indicate node status based on intraoperative signal.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Magnetite Nanoparticles / Sentinel Lymph Node Limits: Animals Language: En Journal: Nanomedicine Journal subject: BIOTECNOLOGIA Year: 2022 Document type: Article Affiliation country:
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Magnetite Nanoparticles / Sentinel Lymph Node Limits: Animals Language: En Journal: Nanomedicine Journal subject: BIOTECNOLOGIA Year: 2022 Document type: Article Affiliation country: