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(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the ß(+)/α(-) interface near the TM2-TM3 loop.
Arias, Hugo R; Borghese, Cecilia M; Germann, Allison L; Pierce, Spencer R; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Thodati, Thanvi M; Lim, Natalie J; Harris, R Adron; Akk, Gustav.
Affiliation
  • Arias HR; Department of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, OK, USA. Electronic address: hugo.arias@okstate.edu.
  • Borghese CM; Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA. Electronic address: cborghese@austin.utexas.edu.
  • Germann AL; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: germanna@wustl.edu.
  • Pierce SR; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: spencerp@wustl.edu.
  • Bonardi A; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Florence, Italy. Electronic address: alessandro.bonardi@unifi.it.
  • Nocentini A; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Florence, Italy. Electronic address: alessio.nocentini@unifi.it.
  • Gratteri P; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Florence, Italy. Electronic address: paola.gratteri@unifi.it.
  • Thodati TM; Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA. Electronic address: thanvi.thodati@utexas.edu.
  • Lim NJ; Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA. Electronic address: natalie.lim@utexas.edu.
  • Harris RA; Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA. Electronic address: harris@austin.utexas.edu.
  • Akk G; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: akk@wustl.edu.
Biochem Pharmacol ; 199: 114993, 2022 05.
Article in En | MEDLINE | ID: mdl-35304861
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Etomidate / Neurosteroids Language: En Journal: Biochem Pharmacol Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Etomidate / Neurosteroids Language: En Journal: Biochem Pharmacol Year: 2022 Document type: Article