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Therapeutic efficacy of the novel SHP2 degrader SHP2-D26, alone or in combination, against lung cancer is associated with modulation of p70S6K/S6, Bim and Mcl-1.
Deng, Yunfu; Ma, Guangzhi; Vallega, Karin A; Wang, Dongsheng; Wang, Mingliang; Wang, Changwei; Wang, Shaomeng; Ramalingam, Suresh S; Sun, Shi-Yong.
Affiliation
  • Deng Y; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.
  • Ma G; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
  • Vallega KA; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
  • Wang D; Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.
  • Wang M; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
  • Wang C; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
  • Wang S; Departments of Medicinal Chemistry, Pharmacology and Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Ramalingam SS; Departments of Medicinal Chemistry, Pharmacology and Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Sun SY; Departments of Medicinal Chemistry, Pharmacology and Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Cancer Gene Ther ; 29(11): 1558-1569, 2022 11.
Article in En | MEDLINE | ID: mdl-35449204
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Cancer Gene Ther Journal subject: GENETICA MEDICA / NEOPLASIAS / TERAPEUTICA Year: 2022 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Cancer Gene Ther Journal subject: GENETICA MEDICA / NEOPLASIAS / TERAPEUTICA Year: 2022 Document type: Article Country of publication: