Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones.
RSC Adv
; 11(39): 24247-24253, 2021 Jul 06.
Article
in En
| MEDLINE
| ID: mdl-35479033
ABSTRACT
A convenient metal-free synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones has been developed. In this procedure, various structural 2-aminopyrimidines, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represents an effective strategy towards the synthesis of unsymmetrical 2-aminopyrimidines.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
RSC Adv
Year:
2021
Document type:
Article