AllocolchicinesâSynthesis with Electro-organic Key Transformations.
Org Lett
; 24(21): 3760-3765, 2022 06 03.
Article
in En
| MEDLINE
| ID: mdl-35503929
ABSTRACT
The naturally occurring colchicine and allocolchicines in the meadow saffron are potentially active ingredients for cancer therapy. A concise protocol for the sustainable synthesis of allocolchicines using up to two electro-organic key transformations is demonstrated. This straightforward synthesis of N-acetylcolchinol methyl ether in a five-step protocol was adopted using protecting groups to enable access to N-acetylcolchinol and the phosphate derivative ZD6126.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Guideline
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2022
Document type:
Article
Affiliation country: