Crystal structures of cocrystals of 2,7-dihydroxynaphthalene with isoniazid and piracetam.
Acta Crystallogr C Struct Chem
; 78(Pt 5): 280-286, 2022 05 01.
Article
in En
| MEDLINE
| ID: mdl-35510433
Cocrystals of 2,7-dihydroxynaphthalene (DHN, or naphthalene-2,7-diol) with isoniazid (pyridine-4-carbohydrazide) (INH), denoted DHN-INH [C10H8O2·C6H7N3O, (I)], and piracetam [2-(2-oxopyrrolidin-1-yl)acetamide] (PIR), denoted DHN-PIR [C10H8O2·C6H10N2O2, (II)], were obtained by the solvent-assisted grinding method and characterized by IR spectroscopy, powder X-ray diffraction and single-crystal X-ray diffraction. Cocrystal (I) crystallized in the triclinic space group P-1 and showed a 2:2 stoichiometry. DHN and INH molecules are connected by O-H...N(pyridine) and O-H...N(hydrazide) hydrogen bonds. Cocrystal (II) crystallized in the space group Pca21 with a 1:1 stoichiometry. DHN and PIR molecules are connected by O-H...O=C hydrogen bonds. The supramolecular architecture of cocrystal (I) showed interlinked supramolecular tapes; meanwhile, in cocrystal (II), interlinked supramolecular sheets were observed.
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Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Piracetam
/
Isoniazid
Language:
En
Journal:
Acta Crystallogr C Struct Chem
Year:
2022
Document type:
Article
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