Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock.
Purinergic Signal
; 18(2): 193-198, 2022 06.
Article
in En
| MEDLINE
| ID: mdl-35522386
ABSTRACT
Historically, mainly by the work of Robert Berne, extracellular adenosine was the first purine compound recognized as an important signaling molecule linking energy metabolism to function by acting on membrane bound receptors. Geoffrey Burnstock by his vision and endurance pioneered the idea that cells release ATP that also acts as an extracellular signaling molecule under many physiological and pathophysiological circumstances. Only later, it was appreciated that extracellular ATP and adenosine are metabolically linked by the activity of several ectoenzymes which critically determine the concentrations of these purines at their respective receptors. In this brief review, I will report some personal recollections on Geoffrey Burnstock and his impressive personality. In addition, I will give a brief overview on our present knowledge of extracellular purine metabolism and its control and will address some still open issues.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenosine
/
Receptors, Purinergic
Language:
En
Journal:
Purinergic Signal
Year:
2022
Document type:
Article
Affiliation country: