Ceftazidime pharmacokinetics in dogs after intravenous injection and delivered with the RxActuator Mini-Infuser infusion pump.
J Vet Emerg Crit Care (San Antonio)
; 32(5): 608-615, 2022 Sep.
Article
in En
| MEDLINE
| ID: mdl-35522422
ABSTRACT
OBJECTIVE:
To test the feasibility of an SC mini-infusion pump to deliver ceftazidime in dogs and produce plasma concentrations sufficient to reach a therapeutic target for 48 hours.SETTING:
University research laboratory. ANIMALS Six healthy Beagle dogs.INTERVENTIONS:
Ceftazidime was administered by 2 routes to 6 healthy Beagle dogs. The first route was an IV bolus injection into a cephalic vein at a dose of 25 mg/kg. Blood samples were collected for 8 hours following injection. The second route was a SC infusion for 48 hours using the RxActuator Mini-Infuser wearable SC constant rate infusion pump. Blood samples were collected for 58 hours following application of the pump. All plasma samples were analyzed by high-pressure liquid chromatography and subject to pharmacokinetic analysis. MAINRESULTS:
After the IV bolus injection, there was rapid distribution and elimination. The elimination half-life was 0.95 hours, and the clearance was rapid at 0.176 ml/h/kg. After the 48-hour SC infusion, the half-life was slightly shorter, and the clearance was higher. The percent bioavailability from the SC infusion was approximately 72%. The SC infusion maintained plasma concentration near our target of 8 µg/ml for most of the dose interval but slightly lower after 24 hours. The concentrations below the target were attributed to slight drug loss, less than 100% bioavailability, and faster clearance from SC administration.CONCLUSIONS:
This study demonstrated the successful application of the RxActuator Mini-Infuser wearable SC constant rate infusion pump for delivering an antimicrobial needed for serious, and sometimes resistant, infections in dogs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Infusion Pumps
/
Ceftazidime
Limits:
Animals
/
Humans
Language:
En
Journal:
J Vet Emerg Crit Care (San Antonio)
Journal subject:
MEDICINA DE EMERGENCIA
/
MEDICINA VETERINARIA
/
TERAPIA INTENSIVA
Year:
2022
Document type:
Article
Affiliation country: