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Progressive multifocal leukoencephalopathy in a patient with systemic lupus erythematosus and autoimmune hepatitis.
Gomathy, Saranya; Panigrahi, Baikuntha; Tirlangi, Praveen Kumar; Wig, Naveet; Brijwal, Megha; Sharma, Mehar C; Garg, Ajay; Tripathi, Manjari; Mohta, Srikant; Doddamani, Ramesh; Vibha, Deepti; Singh, Rajesh Kumar; Yadav, Rajni; Sahu, Saumya; Suri, Vaishali; Kaur, Kavneet; Tripathi, Madhavi; Rohatgi, Anshu; Elavarasi, Arunmozhimaran.
Affiliation
  • Gomathy S; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Panigrahi B; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Tirlangi PK; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Wig N; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Brijwal M; Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
  • Sharma MC; Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
  • Garg A; Department of Neuroimaging and Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India.
  • Tripathi M; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Mohta S; Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
  • Doddamani R; Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
  • Vibha D; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Singh RK; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Yadav R; Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
  • Sahu S; Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
  • Suri V; Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
  • Kaur K; Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
  • Tripathi M; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Rohatgi A; Department of Neurology, Sir Ganga Ram Hospital, New Delhi, India.
  • Elavarasi A; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Int J Rheum Dis ; 25(6): 705-713, 2022 Jun.
Article in En | MEDLINE | ID: mdl-35535671
ABSTRACT
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating central nervous system illness encountered in the setting of immunosuppressive conditions like human immunodeficiency virus / acquired immunodeficiency syndrome, autoimmune diseases and hematologic malignancies. We had a 54-year-old woman with systemic lupus erythematosus and coexisting autoimmune hepatitis who presented with progressive cognitive decline, right hemiparesis and ataxia who was found to have PML. She had severe CD4 lymphopenia. She was managed with low-dose prednisolone and plasma exchange after which she showed significant clinical improvement. This case highlights the diagnostic and therapeutic challenges encountered in managing a case of PML in the setting of autoimmune conditions with profound lymphopenia.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukoencephalopathy, Progressive Multifocal / Hepatitis, Autoimmune / Lupus Erythematosus, Systemic / Lymphopenia Type of study: Diagnostic_studies / Etiology_studies Limits: Female / Humans / Middle aged Language: En Journal: Int J Rheum Dis Journal subject: REUMATOLOGIA Year: 2022 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukoencephalopathy, Progressive Multifocal / Hepatitis, Autoimmune / Lupus Erythematosus, Systemic / Lymphopenia Type of study: Diagnostic_studies / Etiology_studies Limits: Female / Humans / Middle aged Language: En Journal: Int J Rheum Dis Journal subject: REUMATOLOGIA Year: 2022 Document type: Article Affiliation country: