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Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells.
Planès, Rémi; Pinilla, Miriam; Santoni, Karin; Hessel, Audrey; Passemar, Charlotte; Lay, Kenneth; Paillette, Perrine; Valadão, Ana-Luiza Chaves; Robinson, Kim Samirah; Bastard, Paul; Lam, Nathaniel; Fadrique, Ricardo; Rossi, Ida; Pericat, David; Bagayoko, Salimata; Leon-Icaza, Stephen Adonai; Rombouts, Yoann; Perouzel, Eric; Tiraby, Michèle; Zhang, Qian; Cicuta, Pietro; Jouanguy, Emmanuelle; Neyrolles, Olivier; Bryant, Clare E; Floto, Andres R; Goujon, Caroline; Lei, Franklin Zhong; Martin-Blondel, Guillaume; Silva, Stein; Casanova, Jean-Laurent; Cougoule, Céline; Reversade, Bruno; Marcoux, Julien; Ravet, Emmanuel; Meunier, Etienne.
Affiliation
  • Planès R; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France; InvivoGen, Toulouse, France; IRIM, University of Montpellier, CNRS, Montpellier, France. Electronic address: remi.planes@ipbs.fr.
  • Pinilla M; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France; InvivoGen, Toulouse, France.
  • Santoni K; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Hessel A; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Passemar C; Molecular Immunity Unit, University of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
  • Lay K; Institute of Medical Biology, Agency of Science, Technology and Research, 8A Biomedical Grove, #06-06 Immunos, 138648 Singapore, Singapore; Laboratory of Human Genetics and Therapeutics, Genome Institute of Singapore (GIS), A(∗)STAR, Singapore, Singapore.
  • Paillette P; InvivoGen, Toulouse, France.
  • Valadão AC; IRIM, University of Montpellier, CNRS, Montpellier, France.
  • Robinson KS; A(∗)STAR Skin Research Laboratories, 11 Mandalay Road, 308232 Singapore, Singapore.
  • Bastard P; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases,
  • Lam N; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK; University of Cambridge, School of Clinical Medicine, Box 111, Cambridge Biomedical Campus, Cambridge CB2 0SP, UK.
  • Fadrique R; Biological and Soft Systems, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK.
  • Rossi I; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Pericat D; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Bagayoko S; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Leon-Icaza SA; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Rombouts Y; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Perouzel E; InvivoGen, Toulouse, France.
  • Tiraby M; InvivoGen, Toulouse, France.
  • Zhang Q; University of Paris, Imagine Institute, Paris, France.
  • Cicuta P; Biological and Soft Systems, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK.
  • Jouanguy E; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases,
  • Neyrolles O; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Bryant CE; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK; University of Cambridge, School of Clinical Medicine, Box 111, Cambridge Biomedical Campus, Cambridge CB2 0SP, UK.
  • Floto AR; Molecular Immunity Unit, University of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
  • Goujon C; IRIM, University of Montpellier, CNRS, Montpellier, France.
  • Lei FZ; A(∗)STAR Skin Research Laboratories, 11 Mandalay Road, 308232 Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, 308232 Singapore, Singapore; Skin Research Institute of Singapore (SRIS), 11 Mandalay Road, 308232 Singapore, Singapore.
  • Martin-Blondel G; Service des Maladies Infectieuses et Tropicales, CHU de Toulouse, Toulouse, France; Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), INSERM UMR1291 - CNRS UMR5051 - Université Toulouse III, Toulouse, France.
  • Silva S; Critical Care Unit, University Hospital of Purpan, Toulouse, France.
  • Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases,
  • Cougoule C; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Reversade B; Institute of Medical Biology, Agency of Science, Technology and Research, 8A Biomedical Grove, #06-06 Immunos, 138648 Singapore, Singapore; Laboratory of Human Genetics and Therapeutics, Genome Institute of Singapore (GIS), A(∗)STAR, Singapore, Singapore; Institute of Molecular and Cell Biolog
  • Marcoux J; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France.
  • Ravet E; InvivoGen, Toulouse, France.
  • Meunier E; Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, Toulouse, France. Electronic address: etienne.meunier@ipbs.fr.
Mol Cell ; 82(13): 2385-2400.e9, 2022 07 07.
Article in En | MEDLINE | ID: mdl-35594856
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epithelial Cells / Inflammasomes / NLR Proteins / Coronavirus 3C Proteases / SARS-CoV-2 / COVID-19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epithelial Cells / Inflammasomes / NLR Proteins / Coronavirus 3C Proteases / SARS-CoV-2 / COVID-19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2022 Document type: Article