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O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.
Kim, Kibum; Yoo, Hee Chan; Kim, Byung Gyu; Kim, Sulhee; Sung, Yulseung; Yoon, Ina; Yu, Ya Chun; Park, Seung Joon; Kim, Jong Hyun; Myung, Kyungjae; Hwang, Kwang Yeon; Kim, Sunghoon; Han, Jung Min.
Affiliation
  • Kim K; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, 03722, South Korea.
  • Yoo HC; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, South Korea.
  • Kim BG; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, South Korea.
  • Kim S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, 44919, South Korea.
  • Sung Y; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea.
  • Yoon I; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, South Korea.
  • Yu YC; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, South Korea.
  • Park SJ; Institute for Artificial Intelligence and Biomedical Research, Medicinal Bioconvergence Research Center, Yonsei University, Incheon, 21983, South Korea.
  • Kim JH; College of Medicine, Gangnam Severance Hospital, Yonsei University, Seoul, 06273, South Korea.
  • Myung K; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, South Korea.
  • Hwang KY; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University, Seoul, 03722, South Korea.
  • Kim S; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, South Korea.
  • Han JM; Department of Biochemistry, School of Medicine, Catholic University of Daegu, Daegu, 42472, South Korea.
Nat Commun ; 13(1): 2904, 2022 05 25.
Article in En | MEDLINE | ID: mdl-35614056
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylglucosamine / Mechanistic Target of Rapamycin Complex 1 / Glucose / Leucine / Leucine-tRNA Ligase Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylglucosamine / Mechanistic Target of Rapamycin Complex 1 / Glucose / Leucine / Leucine-tRNA Ligase Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: