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Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Kinnebrew, Maia; Woolley, Rachel E; Ansell, T Bertie; Byrne, Eamon F X; Frigui, Sara; Luchetti, Giovanni; Sircar, Ria; Nachtergaele, Sigrid; Mydock-McGrane, Laurel; Krishnan, Kathiresan; Newstead, Simon; Sansom, Mark S P; Covey, Douglas F; Siebold, Christian; Rohatgi, Rajat.
Affiliation
  • Kinnebrew M; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Woolley RE; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Ansell TB; Department of Biochemistry, University of Oxford, Oxford, UK.
  • Byrne EFX; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Frigui S; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Luchetti G; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Sircar R; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Nachtergaele S; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Mydock-McGrane L; Department of Developmental Biology, Washington School of Medicine, St. Louis, MO, USA.
  • Krishnan K; Department of Developmental Biology, Washington School of Medicine, St. Louis, MO, USA.
  • Newstead S; Department of Biochemistry, University of Oxford, Oxford, UK.
  • Sansom MSP; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
  • Covey DF; Department of Biochemistry, University of Oxford, Oxford, UK.
  • Siebold C; Department of Developmental Biology, Washington School of Medicine, St. Louis, MO, USA.
  • Rohatgi R; Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO, USA.
Sci Adv ; 8(22): eabm5563, 2022 06 03.
Article in En | MEDLINE | ID: mdl-35658032
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine / Hedgehog Proteins Language: En Journal: Sci Adv Year: 2022 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine / Hedgehog Proteins Language: En Journal: Sci Adv Year: 2022 Document type: Article Affiliation country: