Characterization of Eosinophilic Esophagitis From the European Pediatric Eosinophilic Esophagitis Registry (pEEr) of ESPGHAN.
J Pediatr Gastroenterol Nutr
; 75(3): 325-333, 2022 09 01.
Article
in En
| MEDLINE
| ID: mdl-35706095
ABSTRACT
OBJECTIVES:
Few pediatric data on phenotypic aspects of eosinophilic esophagitis (EoE) are available. The pEEr registry was developed to prospectively characterize children with EoE from Europe and Israel.METHODS:
pEEr is an ongoing prospective registry enrolling children with esophageal eosinophilia (≥15 eos/HPF). Anonymized data were collected from 19 pediatric centers. Data regarding demographics, clinical manifestations, endoscopy, histology, and therapies were collected.RESULTS:
A total of 582 subjects (61% male) were analyzed. The median age at diagnosis was 10.5 years [interquartile range (IQR) 5.7-17.7], whereas the age at symptom onset was 9.2 years (IQR 4.3-16.4), resulting in a median diagnostic delay of 1.2 years (IQR 0.7-2.3). The diagnostic delay was longer below age <6 years. Shorter diagnostic delays were associated with the presence of food allergy or a family history for EoE. Symptoms varied by age with dysphagia and food impaction more common in adolescents, while vomiting and failure to thrive more common in younger children ( P < 0.001). Among endoscopic findings, esophageal rings were more common in adolescents, whereas exudates were more frequent in younger children( P < 0.001). Patients who responded to proton pump inhibitors (PPIs) were more likely to be older, males, and less often presented severe endoscopic findings. Patients unresponsive to PPIs received topical steroids (40%), elimination diet (41%), or a combined therapy (19%).CONCLUSIONS:
EoE findings vary according to age in pediatric EoE. Young children are commonly characterized by non-specific symptoms, atopic dermatitis, food allergy, and inflammatory endoscopic lesions. Adolescents usually have dysphagia or food impaction, fibrostenotic lesions, and a better PPI response.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Deglutition Disorders
/
Eosinophilic Esophagitis
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Food Hypersensitivity
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Adolescent
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Child
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Child, preschool
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Female
/
Humans
/
Male
Language:
En
Journal:
J Pediatr Gastroenterol Nutr
Year:
2022
Document type:
Article
Affiliation country: