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Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy.
Chatzopoulou, Maria; Conole, Daniel; Emer, Enrico; Rowley, Jessica A; Willis, Nicky J; Squire, Sarah E; Gill, Becky; Brough, Steve; Wilson, Francis X; Wynne, Graham M; Davies, Stephen G; Davies, Kay E; Russell, Angela J.
Affiliation
  • Chatzopoulou M; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
  • Conole D; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
  • Emer E; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
  • Rowley JA; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
  • Willis NJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
  • Squire SE; Department of Physiology, Anatomy and Genetics, University of Oxford, Sir Henry Wellcome Building of Gene Function, South Parks Road, Oxford OX1 3PT, UK.
  • Gill B; Key Organics Ltd, Highfield Road Industrial Estate, Camelford, Cornwall PL32 9RA, UK.
  • Brough S; Key Organics Ltd, Highfield Road Industrial Estate, Camelford, Cornwall PL32 9RA, UK.
  • Wilson FX; Summit Therapeutics Plc, 136a Eastern Avenue, Milton Park, Abingdon, Oxfordshire OX14 4SB, UK.
  • Wynne GM; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
  • Davies SG; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
  • Davies KE; Department of Physiology, Anatomy and Genetics, University of Oxford, Sir Henry Wellcome Building of Gene Function, South Parks Road, Oxford OX1 3PT, UK.
  • Russell AJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3PQ, UK.
Bioorg Med Chem ; 69: 116812, 2022 09 01.
Article in En | MEDLINE | ID: mdl-35772287
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscular Dystrophy, Duchenne Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscular Dystrophy, Duchenne Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Affiliation country: Country of publication: