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Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics.
Orris, Benjamin; Huynh, Kevin W; Ammirati, Mark; Han, Seungil; Bolaños, Ben; Carmody, Jason; Petroski, Matthew D; Bosbach, Benedikt; Shields, David J; Stivers, James T.
Affiliation
  • Orris B; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine 725 North Wolfe Street Baltimore, MD 21205, USA.
  • Huynh KW; Medicine Design, Pfizer, Groton, CT 06340, USA.
  • Ammirati M; Medicine Design, Pfizer, Groton, CT 06340, USA.
  • Han S; Medicine Design, Pfizer, Groton, CT 06340, USA.
  • Bolaños B; Oncology Research and Development, Pfizer, San Diego, CA 92121, USA.
  • Carmody J; Oncology Research and Development, Pfizer, San Diego, CA 92121, USA.
  • Petroski MD; Oncology Research and Development, Pfizer, San Diego, CA 92121, USA.
  • Bosbach B; Centers for Therapeutic Innovation (CTI), Pfizer, NY, NY 10016, USA.
  • Shields DJ; Centers for Therapeutic Innovation (CTI), Pfizer, NY, NY 10016, USA.
  • Stivers JT; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine 725 North Wolfe Street Baltimore, MD 21205, USA.
Nucleic Acids Res ; 50(13): 7545-7559, 2022 07 22.
Article in En | MEDLINE | ID: mdl-35801923
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monomeric GTP-Binding Proteins / SAM Domain and HD Domain-Containing Protein 1 Language: En Journal: Nucleic Acids Res Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monomeric GTP-Binding Proteins / SAM Domain and HD Domain-Containing Protein 1 Language: En Journal: Nucleic Acids Res Year: 2022 Document type: Article Affiliation country: Country of publication: