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QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis.
Vu, Michelle N; Lokugamage, Kumari G; Plante, Jessica A; Scharton, Dionna; Bailey, Aaron O; Sotcheff, Stephanea; Swetnam, Daniele M; Johnson, Bryan A; Schindewolf, Craig; Alvarado, R Elias; Crocquet-Valdes, Patricia A; Debbink, Kari; Weaver, Scott C; Walker, David H; Russell, William K; Routh, Andrew L; Plante, Kenneth S; Menachery, Vineet D.
Affiliation
  • Vu MN; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
  • Lokugamage KG; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
  • Plante JA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
  • Scharton D; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX 77555.
  • Bailey AO; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555.
  • Sotcheff S; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
  • Swetnam DM; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX 77555.
  • Johnson BA; World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555.
  • Schindewolf C; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555.
  • Alvarado RE; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555.
  • Crocquet-Valdes PA; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555.
  • Debbink K; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
  • Weaver SC; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
  • Walker DH; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
  • Russell WK; Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX.
  • Routh AL; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555.
  • Plante KS; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21211.
  • Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Proc Natl Acad Sci U S A ; 119(32): e2205690119, 2022 08 09.
Article in En | MEDLINE | ID: mdl-35881779
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Furin / Proteolysis / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Furin / Proteolysis / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Country of publication: