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Cutting Edge: Hyperinflammatory Monocytes Expressing CD56 Abound in Severe COVID-19 Patients.
Campana, Stefania; De Pasquale, Claudia; Sidoti Migliore, Giacomo; Pezzino, Gaetana; Cavaliere, Riccardo; Venanzi Rullo, Emmanuele; Nunnari, Giuseppe; Caramori, Gaetano; David, Antonio; Bonaccorsi, Irene; Pollicino, Teresa; Carrega, Paolo; Ferlazzo, Guido.
Affiliation
  • Campana S; Laboratory of Immunology and Biotherapy, Department of Human Pathology, University of Messina, Messina, Italy.
  • De Pasquale C; Laboratory of Immunology and Biotherapy, Department of Human Pathology, University of Messina, Messina, Italy.
  • Sidoti Migliore G; Immunology Unit, Department of Experimental Medicine, University of Genoa, Genoa, Italy.
  • Pezzino G; Laboratory of Immunology and Biotherapy, Department of Human Pathology, University of Messina, Messina, Italy.
  • Cavaliere R; Laboratory of Immunology and Biotherapy, Department of Human Pathology, University of Messina, Messina, Italy.
  • Venanzi Rullo E; Clinical Pathology Unit, University Hospital Policlinico "G. Martino," Messina, Italy.
  • Nunnari G; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Caramori G; Unit of Infectious Diseases, University Hospital Policlinico "G. Martino," Messina, Italy.
  • David A; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Bonaccorsi I; Unit of Infectious Diseases, University Hospital Policlinico "G. Martino," Messina, Italy.
  • Pollicino T; Department BIOMORF, University of Messina, Messina, Italy.
  • Carrega P; Pulmonology Unit, University Hospital Policlinico "G. Martino," Messina, Italy.
  • Ferlazzo G; Department of Human Pathology, University of Messina, Messina, Italy.
J Immunol ; 209(4): 655-659, 2022 08 15.
Article in En | MEDLINE | ID: mdl-35896335
Proinflammatory monocytes play a preponderant role in the development of a cytokine storm causing fatal consequences in coronavirus disease 2019 (COVID-19) patients, highlighting the importance of analyzing in more detail monocyte distribution in these patients. In this study, we identified an atypical monocyte subpopulation expressing CD56 molecules that showed a low level of HLA-DR and high level of l-selectin. They released higher amounts of TNF-α and IL-6 and expressed genes associated with an excessive inflammatory process. Remarkably, the frequency of CD56+ monocytes inversely correlated with that of CD16+ monocytes and a high CD56+/CD16+monocyte ratio was associated with both disease severity and mortality, as well as with serum concentration of type I IFN, a factor able to induce the appearance of CD56+ monocytes. In conclusion, severe COVID-19 is characterized by the abundance of hyperinflammatory CD56+ monocytes, which could represent a novel marker with prognostic significance and, possibly, a therapeutic target for controlling the inflammatory process occurring during COVID-19.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / COVID-19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Immunol Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / COVID-19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Immunol Year: 2022 Document type: Article Affiliation country: Country of publication: