Prevalence and Clinical Characteristics of Paraproteinemia Associated with Chronic Myeloid Leukemia.
Acta Haematol
; 145(6): 619-626, 2022.
Article
in En
| MEDLINE
| ID: mdl-35908535
ABSTRACT
INTRODUCTION:
Data regarding the prevalence of paraproteinemia in patients with chronic myeloid leukemia (CML) are lacking.METHODS:
To evaluate for the prevalence of paraproteinemia, we undertook this cross-sectional study among consecutive chronic-phase CML patients. Complete blood count, chemistry, immunoglobulins, serum-free light chains, serum-protein electrophoresis and immunofixation were collected. Further analyses evaluated whether various patient-, disease-, and treatment-related variables are associated with paraproteinemia.RESULTS:
One hundred patients, median age 63.5 (IQR 48.1-72) years were recruited. Median time from CML diagnosis to enrollment was 6.3 (IQR 2.3-11.3) years. Monoclonal protein was detected in 8 patients (8%), diagnosed with smoldering multiple myeloma (SMM, n = 2) and low-risk monoclonal gammopathy of undetermined significance (MGUS, n = 6). Six patients were on tyrosine kinase inhibitor treatment, 2 were in treatment-free remission. The only covariate associated with paraproteinemia was the presence of anemia, albeit with borderline statistical significance in univariate analysis (p = 0.053) and when adjusted for age (p = 0.056).CONCLUSIONS:
In this largest study so far describing the prevalence of paraproteinemia among CML patients, we found MGUS prevalence to be higher than the 3.2% expected prevalence in the general population above 50 years and a non-negligible prevalence of SMM (2%). Screening for paraproteinemia in CML patients, especially in the presence of anemia, should be considered.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraproteinemias
/
Monoclonal Gammopathy of Undetermined Significance
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Leukemia, Myeloid
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Multiple Myeloma
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Humans
/
Middle aged
Language:
En
Journal:
Acta Haematol
Year:
2022
Document type:
Article
Affiliation country: