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A genome-wide association study of total child psychiatric problems scores.
Neumann, Alexander; Nolte, Ilja M; Pappa, Irene; Ahluwalia, Tarunveer S; Pettersson, Erik; Rodriguez, Alina; Whitehouse, Andrew; van Beijsterveldt, Catharina E M; Benyamin, Beben; Hammerschlag, Anke R; Helmer, Quinta; Karhunen, Ville; Krapohl, Eva; Lu, Yi; van der Most, Peter J; Palviainen, Teemu; St Pourcain, Beate; Seppälä, Ilkka; Suarez, Anna; Vilor-Tejedor, Natalia; Tiesler, Carla M T; Wang, Carol; Wills, Amanda; Zhou, Ang; Alemany, Silvia; Bisgaard, Hans; Bønnelykke, Klaus; Davies, Gareth E; Hakulinen, Christian; Henders, Anjali K; Hyppönen, Elina; Stokholm, Jakob; Bartels, Meike; Hottenga, Jouke-Jan; Heinrich, Joachim; Hewitt, John; Keltikangas-Järvinen, Liisa; Korhonen, Tellervo; Kaprio, Jaakko; Lahti, Jari; Lahti-Pulkkinen, Marius; Lehtimäki, Terho; Middeldorp, Christel M; Najman, Jackob M; Pennell, Craig; Power, Chris; Oldehinkel, Albertine J; Plomin, Robert; Räikkönen, Katri; Raitakari, Olli T.
Affiliation
  • Neumann A; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Nolte IM; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
  • Pappa I; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Ahluwalia TS; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Pettersson E; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Rodriguez A; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Whitehouse A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • van Beijsterveldt CEM; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Benyamin B; Telethon Kids Institute, University of Western Australia, Perth, Australia.
  • Hammerschlag AR; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
  • Helmer Q; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, Australia.
  • Karhunen V; South Australian Health and Medical Research Institute, Adelaide, Australia.
  • Krapohl E; Child Health Research Centre, University of Queensland, Brisbane, QLD, Australia.
  • Lu Y; Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • van der Most PJ; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
  • Palviainen T; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
  • St Pourcain B; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Seppälä I; Centre for Life-Course Health Research, University of Oulu, Oulu, Finland.
  • Suarez A; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
  • Vilor-Tejedor N; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Tiesler CMT; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Wang C; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Wills A; MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
  • Zhou A; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherland.
  • Alemany S; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
  • Bisgaard H; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
  • Bønnelykke K; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Davies GE; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Hakulinen C; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Henders AK; BarcelonaBeta Brain Research Center (BBRC)-Pasqual Maragall Foundation, Barcelona, Spain.
  • Hyppönen E; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Stokholm J; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Bartels M; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Hottenga JJ; LMU-Ludwig-Maximilians-Universität Munich, Div. Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
  • Heinrich J; School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia.
  • Hewitt J; Division of Substance Dependence, Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.
  • Keltikangas-Järvinen L; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, United States of America.
  • Korhonen T; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, Australia.
  • Kaprio J; South Australian Health and Medical Research Institute, Adelaide, Australia.
  • Lahti J; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Lahti-Pulkkinen M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
  • Lehtimäki T; CIBER Epidemiology and Public Health (CIBERESP), Barcelona, Spain.
  • Middeldorp CM; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Najman JM; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Pennell C; Avera Institute for Human Genetics, Sioux Falls, South Dakota, United States of America.
  • Power C; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Oldehinkel AJ; Institute of Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
  • Plomin R; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, Australia.
  • Räikkönen K; South Australian Health and Medical Research Institute, Adelaide, Australia.
  • Raitakari OT; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
PLoS One ; 17(8): e0273116, 2022.
Article in En | MEDLINE | ID: mdl-35994476
ABSTRACT
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide

significance:

rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Attention Deficit Disorder with Hyperactivity / Bipolar Disorder Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2022 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Attention Deficit Disorder with Hyperactivity / Bipolar Disorder Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2022 Document type: Article Affiliation country: