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Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium.
Ivanov, Iliyan; Boedhoe, Premika S W; Abe, Yoshinari; Alonso, Pino; Ameis, Stephanie H; Arnold, Paul D; Balachander, Srinivas; Baker, Justin T; Banaj, Nerisa; Bargalló, Nuria; Batistuzzo, Marcelo C; Benedetti, Francesco; Beucke, Jan C; Bollettini, Irene; Brem, Silvia; Brennan, Brian P; Buitelaar, Jan; Calvo, Rosa; Cheng, Yuqi; Cho, Kang Ik K; Dallaspezia, Sara; Denys, Damiaan; Diniz, Juliana B; Ely, Benjamin A; Feusner, Jamie D; Ferreira, Sónia; Fitzgerald, Kate D; Fontaine, Martine; Gruner, Patricia; Hanna, Gregory L; Hirano, Yoshiyuki; Hoexter, Marcelo Q; Huyser, Chaim; Ikari, Keisuke; James, Anthony; Jaspers-Fayer, Fern; Jiang, Hongyan; Kathmann, Norbert; Kaufmann, Christian; Kim, Minah; Koch, Kathrin; Kwon, Jun Soo; Lázaro, Luisa; Liu, Yanni; Lochner, Christine; Marsh, Rachel; Martínez-Zalacaín, Ignacio; Mataix-Cols, David; Menchón, José M; Minuzzi, Luciano.
Affiliation
  • Ivanov I; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Boedhoe PSW; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, the Netherlands.
  • Abe Y; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Alonso P; Department of Clinical Sciences, Bellvitge Biomedical Research Institute-IDIBELL, CIBERSAM, Bellvitge University Hospital, Barcelona, Spain.
  • Ameis SH; The Margaret and Wallace McCain Centre for Child, Youth & Family Mental Health, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada.
  • Arnold PD; The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Balachander S; Obsessive-Compulsive Disorder (OCD) Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
  • Baker JT; McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.
  • Banaj N; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Bargalló N; Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Image Diagnostic Center, Hospital Clinic of Barcelona, Barcelona, Spain.
  • Batistuzzo MC; Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil; Department of Methods and Techniques in Psychology, Pontifical Catholic University of Sao Paulo, SP, Brazil.
  • Benedetti F; Vita-Salute San Raffaele University, Milano, Italy; Departments of Psychiatry and Medical Genetics, IRCCS Scientific Institute Ospedale San Raffaele, Milan, Italy.
  • Beucke JC; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
  • Bollettini I; Departments of Psychiatry and Medical Genetics, IRCCS Scientific Institute Ospedale San Raffaele, Milan, Italy.
  • Brem S; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
  • Brennan BP; McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.
  • Buitelaar J; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Calvo R; Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic of Barcelona (CIBERSAM), Department of Medicine, University of Barcelona, Barcelona, Spain.
  • Cheng Y; Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
  • Cho KIK; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Brain and Cognitive Sciences, Seoul University College
  • Dallaspezia S; Departments of Psychiatry and Medical Genetics, IRCCS Scientific Institute Ospedale San Raffaele, Milan, Italy.
  • Denys D; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands.
  • Diniz JB; Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil.
  • Ely BA; Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, New York, NY, USA.
  • Feusner JD; Division of Neurosciences & Clinical Translation, Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Staglin IMHRO Center for Cognitive Neuroscience, Jane &
  • Ferreira S; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, ICVS/3B's PT Government Associate Laboratory, Clinical Academic Center, Braga, Portugal.
  • Fitzgerald KD; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
  • Fontaine M; Columbia University Irving Medical Center, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
  • Gruner P; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
  • Hanna GL; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
  • Hirano Y; Research Center for Child Mental Development, Chiba University, Chiba, Japan.
  • Hoexter MQ; Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil.
  • Huyser C; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands; Levvel Academic Center for Child and Adolescent Psychiatry, Amsterdam, the Netherlands.
  • Ikari K; Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • James A; Department of Psychiatry, Oxford University, Oxford, UK.
  • Jaspers-Fayer F; Britsh Columbia Children's Hospital, BC Mental Health and Substance Use Services Research, University of British Columbia, Vancouver, BC, Canada.
  • Jiang H; Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
  • Kathmann N; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Kaufmann C; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Kim M; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
  • Koch K; Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Germany.
  • Kwon JS; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Brain and Cognitive Sciences, Seoul University College of Natural Science, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
  • Lázaro L; Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic of Barcelona (CIBERSAM), Department of Medicine, University of Barcelona, Barcelona, Spain.
  • Liu Y; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
  • Lochner C; SAMRC Unit on Anxiety & Stress Disorders, Department of Psychiatry, Stellenbosch University, South Africa.
  • Marsh R; Columbia University Irving Medical Center, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
  • Martínez-Zalacaín I; Department of Clinical Sciences, Bellvitge Biomedical Research Institute-IDIBELL, CIBERSAM, Bellvitge University Hospital, Barcelona, Spain.
  • Mataix-Cols D; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
  • Menchón JM; Department of Clinical Sciences, Bellvitge Biomedical Research Institute-IDIBELL, CIBERSAM, Bellvitge University Hospital, Barcelona, Spain.
  • Minuzzi L; Department of Psychiatry and Behavioral Neurosciences, McMaster University, St. Joseph's Health Care, Hamilton, Ontario, Canada.
J Affect Disord ; 318: 204-216, 2022 12 01.
Article in En | MEDLINE | ID: mdl-36041582
ABSTRACT

BACKGROUND:

Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs.

METHODS:

The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6-65) was divided into six successive 6-10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients.

RESULTS:

Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6-13 and adults aged 50-65 with OCD taking SRIs (Cohen's d = -0.24 to -0.74). Volumes of putamen, pallidum (d = 0.18-0.40), and ventricles (d = 0.31-0.66) were greater in patients aged 20-29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = -0.27 to -1.31).

CONCLUSIONS:

Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20-29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antipsychotic Agents / Obsessive-Compulsive Disorder Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Aged / Child / Child, preschool / Humans Language: En Journal: J Affect Disord Year: 2022 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antipsychotic Agents / Obsessive-Compulsive Disorder Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Aged / Child / Child, preschool / Humans Language: En Journal: J Affect Disord Year: 2022 Document type: Article Affiliation country: