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Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe, Tomoya; Takagi, Masatoshi; Sato-Otsubo, Aiko; Nishimura, Akira; Nagae, Genta; Yamagishi, Chika; Tamura, Moe; Tanaka, Yosuke; Asada, Shuhei; Takeda, Reina; Tsuchiya, Akiho; Wang, Xiaonan; Yoshida, Kenichi; Nannya, Yasuhito; Ueno, Hiroo; Akazawa, Ryo; Kato, Itaru; Mikami, Takashi; Watanabe, Kentaro; Sekiguchi, Masahiro; Seki, Masafumi; Kimura, Shunsuke; Hiwatari, Mitsuteru; Kato, Motohiro; Fukuda, Shiro; Tatsuno, Kenji; Tsutsumi, Shuichi; Kanai, Akinori; Inaba, Toshiya; Shiozawa, Yusuke; Shiraishi, Yuichi; Chiba, Kenichi; Tanaka, Hiroko; Kotecha, Rishi S; Cruickshank, Mark N; Ishikawa, Fumihiko; Morio, Tomohiro; Eguchi, Mariko; Deguchi, Takao; Kiyokawa, Nobutaka; Arakawa, Yuki; Koh, Katsuyoshi; Aoki, Yuki; Ishihara, Takashi; Tomizawa, Daisuke; Miyamura, Takako; Ishii, Eiichi; Mizutani, Shuki; Wilson, Nicola K; Göttgens, Berthold.
Affiliation
  • Isobe T; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Takagi M; Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Sato-Otsubo A; Department of Hematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, UK.
  • Nishimura A; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan. m.takagi.ped@tmd.ac.jp.
  • Nagae G; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Yamagishi C; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
  • Tamura M; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
  • Tanaka Y; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
  • Asada S; Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Takeda R; Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Tsuchiya A; Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Wang X; The Institute of Laboratory Animals, Tokyo Women's Medical University, Tokyo, Japan.
  • Yoshida K; Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Nannya Y; Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Ueno H; Department of Hematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, UK.
  • Akazawa R; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kato I; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Mikami T; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Watanabe K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Sekiguchi M; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Seki M; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kimura S; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Hiwatari M; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kato M; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Fukuda S; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Tatsuno K; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Tsutsumi S; Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
  • Kanai A; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Inaba T; Department of Pediatrics, School of Medicine, Teikyo University, Tokyo, Japan.
  • Shiozawa Y; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Shiraishi Y; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
  • Chiba K; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
  • Tanaka H; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
  • Kotecha RS; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
  • Cruickshank MN; Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
  • Ishikawa F; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Morio T; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
  • Eguchi M; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
  • Deguchi T; Department of Integrated Data Science, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
  • Kiyokawa N; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
  • Arakawa Y; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, WA, Australia.
  • Koh K; Curtin Medical School, Curtin University, Perth, WA, Australia.
  • Aoki Y; School of Biomedical Sciences, University of Western Australia, Nedlands, WA, Australia.
  • Ishihara T; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Tomizawa D; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
  • Miyamura T; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.
  • Ishii E; Division of Cancer Immunodiagnostics, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
  • Mizutani S; Department of Pediatrics, Graduate School of Medicine, Mie University, Tsu, Japan.
  • Wilson NK; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Göttgens B; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Nat Commun ; 13(1): 4501, 2022 08 30.
Article in En | MEDLINE | ID: mdl-36042201
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone-Lysine N-Methyltransferase / Myeloid-Lymphoid Leukemia Protein / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Prognostic_studies Limits: Humans / Infant Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone-Lysine N-Methyltransferase / Myeloid-Lymphoid Leukemia Protein / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Prognostic_studies Limits: Humans / Infant Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: