DNA-Mediated Control of Protein Function in Semi-Synthetic Systems.
Chembiochem
; 23(24): e202200464, 2022 12 16.
Article
in En
| MEDLINE
| ID: mdl-36058885
ABSTRACT
The development of strategies for controlling protein function in a precise and predictable manner has the potential to revolutionize catalysis, diagnostics, and medicine. In this regard, the use of DNA has emerged as a powerful approach for modulating protein activity. The programmable nature of DNA allows for constructing sophisticated architectures wherein proteins can be placed with control over position, orientation, and stoichiometry. This ability is especially useful considering that the properties of proteins can be influenced by their local environment or their proximity to other functional molecules. Here, we chronicle the different strategies that have been developed to interface DNA with proteins in semi-synthetic systems. We further delineate the unique applications unlocked by the unprecedented level of structural control that DNA affords. We end by outlining outstanding challenges in the area and discuss future research directions towards potential solutions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nanotechnology
/
Nanostructures
Language:
En
Journal:
Chembiochem
Journal subject:
BIOQUIMICA
Year:
2022
Document type:
Article
Affiliation country: