Constructions of synergistic photothermal therapy antibacterial hydrogel based on polydopamine, tea polyphenols and polyvinyl alcohol and effects on wound healing in mouse.

ABSTRACT

Hydrogels with significant antibacterial efficacy have enormous potential in wound healing. This work reported a series of effective antibacterial and antioxidant hydrogels based on tea polyphenols (TP), polydopamine (PDA), and polyvinyl alcohol (PVA). PDA-TP molecular chains are formed from oxidized TP and PDA. These molecular chains, which were cross-linked with PVA by cyclic freeze-thaw (FT), formed the PVA/PDA-TP hydrogel (PPTP). The number of freezing-thawing cycles and the amount of TP would affect the mechanical properties and swelling properties of hydrogel. The PPTP hydrogel exhibited high photo thermal conversion efficiency, high antibacterial efficacy, antioxidant properties, good cellular compatibility and short wound closure time. The PPTP hydrogel leaded to wound closure in approximately 10 d in a full-thickness skin defect mouse model. The preparation method of hydrogel with non-chemical cross-linked and ability of rapid high temperature generation provided a new way to apply TP to wound healing and proved that synergistic chemical and photothermal therapy can effectively inhibit resistant bacteria and accelerate wound healing.