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A honeybee stinger-inspired self-interlocking microneedle patch and its application in myocardial infarction treatment.
Lu, Yuwen; Ren, Tanchen; Zhang, Hua; Jin, Qiao; Shen, Liyin; Shan, Mengqi; Zhao, Xinzhe; Chen, Qichao; Dai, Haoli; Yao, Lin; Xie, Jieqi; Ye, Di; Lin, Tengxiang; Hong, Xiaoqian; Deng, Kaicheng; Shen, Ting; Pan, Jiazhen; Jia, Mengyan; Ling, Jun; Li, Peng; Zhang, Yue; Wang, Huanan; Zhuang, Lenan; Gao, Changyou; Mao, Jifu; Zhu, Yang.
Affiliation
  • Lu Y; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Ren T; Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
  • Zhang H; College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
  • Jin Q; Institute of Genetics and Reproduction, College of Animal Sciences, Zhejiang University, Hangzhou, China.
  • Shen L; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Shan M; College of Textiles, Donghua University, Shanghai 201620, China.
  • Zhao X; Shanghai Banyun Med Tech Co., Ltd., Shanghai 201203, China.
  • Chen Q; Shanghai Banyun Med Tech Co., Ltd., Shanghai 201203, China.
  • Dai H; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Yao L; State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Xie J; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Ye D; College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
  • Lin T; State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Hong X; Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
  • Deng K; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Shen T; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Pan J; College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
  • Jia M; College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
  • Ling J; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Li P; State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • Zhang Y; San Francisco Veterans Affairs Medical Center, CA 94121, USA.
  • Wang H; College of Animal Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: hnwang@zju.edu.cn.
  • Zhuang L; Institute of Genetics and Reproduction, College of Animal Sciences, Zhejiang University, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangz
  • Gao C; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: cygao@zju.edu.cn.
  • Mao J; College of Textiles, Donghua University, Shanghai 201620, China. Electronic address: jifu.mao@dhu.edu.cn.
  • Zhu Y; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China; Binjiang Institute of Zhejiang University, Hangzhou 310053 China. Electronic address: zhuyang@zju.edu.cn.
Acta Biomater ; 153: 386-398, 2022 11.
Article in En | MEDLINE | ID: mdl-36116725
ABSTRACT
Weak tissue adhesion remains a major challenge in clinical translation of microneedle patches. Mimicking the structural features of honeybee stingers, stiff polymeric microneedles with unidirectionally backward-facing barbs were fabricated and embedded into various elastomer films to produce self-interlocking microneedle patches. The spirality of the barbing pattern was adjusted to increase interlocking efficiency. In addition, the micro-bleeding caused by microneedle puncturing adhered the porous surface of the patch substrate to the target tissue via coagulation. In the demonstrative application of myocardial infarction treatment, the bioinspired microneedle patches firmly fixed on challenging beating hearts, significantly reduced cardiac wall stress and strain in the infarct, and maintained left ventricular function and morphology. In addition, the microneedle patch was minimally invasively implanted onto beating porcine heart in 10 minutes, free of sutures and adhesives. Therefore, the honeybee stinger-inspired microneedles could provide an adaptive and convenient means to implant patches for various medical applications. STATEMENT OF

SIGNIFICANCE:

Adhesion between tissue and microneedle patches with smooth microneedles is usually weak. We introduce a novel barbing method of fabricating unidirectionally backward facing barbs with controllable spirality on the microneedles on microneedle patches. The microneedle patches self-interlock on mechanically dynamic beating hearts, similar to honeybee stingers. The micro-bleeding and coagulation on the porous surface provide additional adhesion force. The microneedle patches attenuate left ventricular remodeling via mechanical support and are compatible with minimally invasive implantation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocardial Infarction / Needles Limits: Animals Language: En Journal: Acta Biomater Year: 2022 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocardial Infarction / Needles Limits: Animals Language: En Journal: Acta Biomater Year: 2022 Document type: Article Affiliation country: