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A Panax quinquefolius-Based Preparation Prevents the Impact of 5-FU on Activity/Exploration Behaviors and Not on Cognitive Functions Mitigating Gut Microbiota and Inflammation in Mice.
Parment, Renaud; Dubois, Martine; Desrues, Laurence; Mutel, Alexandre; Dembélé, Kléouforo-Paul; Belin, Nicolas; Tron, Laure; Guérin, Charlène; Coëffier, Moïse; Compère, Vincent; Féger, Céline; Joly, Florence; Hilber, Pascal; Ribet, David; Castel, Hélène.
Affiliation
  • Parment R; Normandie University, UNIROUEN, INSERM, U1245, Cancer and Brain Genomics, 76000 Rouen, France.
  • Dubois M; Institute for Research and Innovation in Biomedicine (IRIB), 76000 Rouen, France.
  • Desrues L; Cancer and Cognition Platform, Ligue Nationale Contre le Cancer, 14000 Caen, France.
  • Mutel A; Normandie University, UNIROUEN, INSERM, U1245, Cancer and Brain Genomics, 76000 Rouen, France.
  • Dembélé KP; Institute for Research and Innovation in Biomedicine (IRIB), 76000 Rouen, France.
  • Belin N; Cancer and Cognition Platform, Ligue Nationale Contre le Cancer, 14000 Caen, France.
  • Tron L; Normandie University, UNIROUEN, INSERM, U1245, Cancer and Brain Genomics, 76000 Rouen, France.
  • Guérin C; Institute for Research and Innovation in Biomedicine (IRIB), 76000 Rouen, France.
  • Coëffier M; Cancer and Cognition Platform, Ligue Nationale Contre le Cancer, 14000 Caen, France.
  • Compère V; Normandie University, UNIROUEN, INSERM, U1245, Cancer and Brain Genomics, 76000 Rouen, France.
  • Féger C; Institute for Research and Innovation in Biomedicine (IRIB), 76000 Rouen, France.
  • Joly F; Cancer and Cognition Platform, Ligue Nationale Contre le Cancer, 14000 Caen, France.
  • Hilber P; Normandie University, UNIROUEN, INSERM, U1245, Cancer and Brain Genomics, 76000 Rouen, France.
  • Ribet D; Institute for Research and Innovation in Biomedicine (IRIB), 76000 Rouen, France.
  • Castel H; Cancer and Cognition Platform, Ligue Nationale Contre le Cancer, 14000 Caen, France.
Cancers (Basel) ; 14(18)2022 Sep 10.
Article in En | MEDLINE | ID: mdl-36139563
Chemotherapy-related cognitive impairment (CRCI) and fatigue constitute common complaints among cancer patient survivors. Panax quinquefolius has been shown to be effective against fatigue in treated cancer patients. We developed a behavioral C57Bl/6j mouse model to study the role of a Panax quinquefolius-based solution containing vitamin C (Qiseng®) or vitamin C alone in activity/fatigue, emotional reactivity and cognitive functions impacted by 5-Fluorouracil (5-FU) chemotherapy. 5-FU significantly reduces the locomotor/exploration activity potentially associated with fatigue, evokes spatial cognitive impairments and leads to a decreased neurogenesis within the hippocampus (Hp). Qiseng® fully prevents the impact of chemotherapy on activity/fatigue and on neurogenesis, specifically in the ventral Hp. We observed that the chemotherapy treatment induces intestinal damage and inflammation associated with increased levels of Lactobacilli in mouse gut microbiota and increased expression of plasma pro-inflammatory cytokines, notably IL-6 and MCP-1. We demonstrated that Qiseng® prevents the 5-FU-induced increase in Lactobacilli levels and further compensates the 5-FU-induced cytokine release. Concomitantly, in the brains of 5-FU-treated mice, Qiseng® partially attenuates the IL-6 receptor gp130 expression associated with a decreased proliferation of neural stem cells in the Hp. In conclusion, Qiseng® prevents the symptoms of fatigue, reduced chemotherapy-induced neuroinflammation and altered neurogenesis, while regulating the mouse gut microbiota composition, thus protecting against intestinal and systemic inflammation.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancers (Basel) Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancers (Basel) Year: 2022 Document type: Article Affiliation country: Country of publication: