Recent two-year advances in anti-dengue small-molecule inhibitors.
Eur J Med Chem
; 243: 114753, 2022 Dec 05.
Article
in En
| MEDLINE
| ID: mdl-36167010
ABSTRACT
Dengue is an acute tropical infectious disease transmitted by mosquitoes, which has posed a major challenge to global public health. Unfortunately, there is a lack of clinically proven dengue-specific drugs for its prevention and treatment. As the pathogenesis of dengue has not been fully elucidated, the development of specific drugs is seriously hindered. This article briefly describes the pathogenesis of dengue fever, the molecular characteristics, and epidemiology of dengue virus, and focuses on the potential small-molecule inhibitors of dengue virus, including on-target and multi-targeted inhibitors, which have been reported in the past two years.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aedes
/
Dengue Virus
Limits:
Animals
Language:
En
Journal:
Eur J Med Chem
Year:
2022
Document type:
Article
Affiliation country: