CHOROIDAL NEVUS ASSOCIATED WITH VITELLIFORM DEPOSITION IN A PATIENT WITH AUTOSOMAL DOMINANT BEST DYSTROPHY.
Retin Cases Brief Rep
; 18(1): 120-123, 2024 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-36240079
ABSTRACT
BACKGROUND/PURPOSE:
To describe the clinical, optical coherence tomography (OCT), fundus autofluorescence and ultrasound findings of a patient with a choroidal nevus actively exuding vitelliform material in the setting of autosomal dominant Best dystrophy (BD).METHODS:
The patient's clinical course was followed over time with ophthalmic examinations and multimodal imaging.RESULTS:
A 71-year-old male patient with BD was referred for evaluation of a choroidal nevus in the right eye. Dilated fundoscopic examination showed a small pigmented choroidal nevus in the temporal periphery. Over a 3-year period, the nevus developed progressive deposition of vitelliform material along its inferior border. Meanwhile, OCT and fundus photography showed only slight growth. Ultrasound showed no change in height; basal measurements were confounded by the increased vitelliform deposits. Genetic testing confirmed a heterozygous mutation in the BEST1 gene and electrophysiology was consistent with BD.CONCLUSIONS:
Dysfunction of the retinal pigment epithelium associated with BD may cause novel presentations of other conditions such as choroidal nevi. The implication for malignant transformation of a choroidal nevus associated with vitelliform deposit accumulation in this context is unknown.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Choroid Neoplasms
/
Vitelliform Macular Dystrophy
/
Nevus
/
Nevus, Pigmented
Type of study:
Risk_factors_studies
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Retin Cases Brief Rep
Year:
2024
Document type:
Article