[Experience of using a triple fixed combination in the treatment of patients with chronic obstructive pulmonary disease].
Ter Arkh
; 94(3): 396-400, 2022 Mar 15.
Article
in Ru
| MEDLINE
| ID: mdl-36286904
ABSTRACT
AIM:
To evaluate the effectiveness of a fixed triple combination of vilanterol/umeclidinium bromide/fluticasone furoate in the treatment of chronic obstructive pulmonary disease (COPD) patients with frequent exacerbations. MATERIALS ANDMETHODS:
The study included 46 patients with severe and extremely severe COPD (GOLD 34) with frequent exacerbations. All patients were divided into 2 groups. The 1st group included 22 COPD patients with a content of eosinophils in the peripheral blood of 300 cells/ml, the 2nd group included 24 COPD patients with no signs of eosinophilic inflammation in the peripheral blood. Group 1 patients were recommended therapy with a fixed triple combination of vilanterol/umeclidinium bromide/fluticasone furoate at a dose of 22/55/92 mcg 1 time per day, group 2 patients received vilanterol+umeclidinium bromide at a dose of 22/55 mcg 1 time per day. The duration of follow-up was 12 months.RESULTS:
After 12 months of treatment with a fixed triple combination of vilanterol/umeclidinium bromide/fluticasone furoate, a statistically significant decrease in peripheral blood eosinophilia was noted in patients with COPD with frequent exacerbations and peripheral blood eosinophilia (p=0.001), as well as a decrease in shortness of breath on the MMRs scale (p=0.001) and the frequency of exacerbations in patients with COPD with frequent exacerbations and eosinophilia (p=0.001).CONCLUSION:
The use of a fixed combination of vilanterol/umeclidinium bromide/fluticasone furoate for 12 months allowed to reduce the impact of the disease, improve respiratory function and quality of life in COPD patients with eosinophilia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bronchodilator Agents
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Diagnostic_studies
Aspects:
Patient_preference
Limits:
Humans
Language:
Ru
Journal:
Ter Arkh
Year:
2022
Document type:
Article