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Cannabis Use Is Inversely Associated with Metabolic Disorders in Hepatitis C-Infected Patients (ANRS CO22 Hepather Cohort).
Barré, Tangui; Bourlière, Marc; Ramier, Clémence; Carrat, Fabrice; Di Beo, Vincent; Protopopescu, Camelia; Marcellin, Fabienne; Bureau, Morgane; Cagnot, Carole; Dorival, Céline; Zoulim, Fabien; Zucman-Rossi, Jessica; Duclos-Vallée, Jean-Charles; Fontaine, Hélène; Carrieri, Patrizia.
Affiliation
  • Barré T; Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.
  • Bourlière M; Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.
  • Ramier C; Hôpital St. Joseph, Service d'Hépato-Gastroentérologie, 13008 Marseille, France.
  • Carrat F; Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.
  • Di Beo V; Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d'Epidémiologie et de Santé Publique, Sorbonne Université, 75012 Paris, France.
  • Protopopescu C; Hôpital Saint-Antoine, Unité de Santé Publique, Assistance Publique-Hôpitaux de Paris (AP-HP), 75012 Paris, France.
  • Marcellin F; Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.
  • Bureau M; Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.
  • Cagnot C; Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.
  • Dorival C; Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.
  • Zoulim F; ANRS|Emerging Infectious Diseases, Department of Clinical Research, 75015 Paris, France.
  • Zucman-Rossi J; Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d'Epidémiologie et de Santé Publique, Sorbonne Université, 75012 Paris, France.
  • Duclos-Vallée JC; INSERM U1052, CNRS UMR-5286, Cancer Research Center of Lyon (CRCL), 69008 Lyon, France.
  • Fontaine H; University of Lyon, Université Claude-Bernard (UCBL), 69007 Lyon, France.
  • Carrieri P; Hospices Civils de Lyon (HCL), 69002 Lyon, France.
  • The Anrs/Afef Hepather Study Group; Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université Paris Cité, 75019 Paris, France.
J Clin Med ; 11(20)2022 Oct 18.
Article in En | MEDLINE | ID: mdl-36294456
ABSTRACT
BACKGROUND AND

AIMS:

Hepatitis C virus (HCV) infection is associated with the onset of metabolic disorders which constitute risk factors for liver disease progression. Their impact may persist after the HCV infection has been cured. Cannabis use is associated with a lower risk of obesity and diabetes in both general and HCV populations. The associations between cannabis use and both dyslipidemia and hypertension have not yet been studied in persons with chronic HCV infection.

METHODS:

Using cross-sectional data from the French ANRS CO22 Hepather cohort, we used regression models to test for an inverse relationship between cannabis use and (i) dyslipidemia, (ii) hypertension, and (iii) the total number of metabolic disorders.

RESULTS:

Among the 6364 participants in the study population, both former and current cannabis use were associated with a lower risk of hypertension and fewer metabolic disorders. These results were independent of central obesity. Cannabis use was not associated with dyslipidemia.

CONCLUSIONS:

In people chronically infected with HCV, cannabis use was associated with a lower risk of hypertension and a lower number of metabolic disorders. Post-HCV cure studies are needed to confirm these findings using longitudinal data and to test whether they translate into reduced mortality in this population.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: J Clin Med Year: 2022 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: J Clin Med Year: 2022 Document type: Article Affiliation country: