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Rational design, synthesis and biological evaluation of novel 2-(substituted amino)-[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors.
Chen, Lin; Ji, Tang-Yang; Huo, Xian-Sen; Zeng, Zhi-Yu; Ye, Wei-Xuan; Dai, Chen-Chen; Zhang, Yu-Qi; You, Wen-Wei; Zhao, Pei-Liang.
Affiliation
  • Chen L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Ji TY; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Huo XS; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Zeng ZY; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Ye WX; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Dai CC; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Zhang YQ; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • You WW; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Zhao PL; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China. Electronic address: plzhao@smu.edu.cn.
Eur J Med Chem ; 244: 114864, 2022 Dec 15.
Article in En | MEDLINE | ID: mdl-36334455
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tubulin Modulators / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tubulin Modulators / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article