Nitroenediamines (EDAMs), and N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) derivatives: scaffolds for heterocycle molecular diversity (update from 2012 to 2021).
RSC Adv
; 12(47): 30436-30456, 2022 Oct 24.
Article
in En
| MEDLINE
| ID: mdl-36337974
ABSTRACT
Nitro-1,1-enediamines (EDAMs) and 1,1-bis(methylthio)-2-nitroethene (NMSN) have proven to be a class of attractive and useful synthetic building blocks for use in the synthesis of heterocyclic and fused heterocyclic compounds. The bicyclic or tricyclic heterocycles derived from these frames widely exist in natural and synthetic drugs. To comprehend the reaction properties of EDAMs and NMSN and to design other novel fused heterocycles with biological effects in the future, it is essential to investigate their recent reactions. The current review envisions highlighting some recent and remarkable examples of nitroenediamine reactions categorized by catalyst-assisted and catalyst-free reactions from 2012 onward.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
RSC Adv
Year:
2022
Document type:
Article