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Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert.
Astakala, Rishi Vachaspathy; Preet, Gagan; Milne, Bruce F; Tibyangye, Julius; Razmilic, Valeria; Castro, Jean Franco; Asenjo, Juan A; Andrews, Barbara; Ebel, Rainer; Jaspars, Marcel.
Affiliation
  • Astakala RV; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UK.
  • Preet G; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UK.
  • Milne BF; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UK.
  • Tibyangye J; CFisUC, Department of Physics, University of Coimbra, Rua Larga, 3004-516 Coimbra, Portugal.
  • Razmilic V; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UK.
  • Castro JF; Department of Medical Laboratory Sciences, Faculty of Health Sciences, Muni University, Arua P.O. Box 725, Uganda.
  • Asenjo JA; Centre for Biotechnology and Bioengineering (CeBiB), University of Chile, Beauchef 851, Santiago 8370459, Región Metropolitana, Chile.
  • Andrews B; Instituto de Investigaciones Agropecuarias, INIA-Quilamapu, Av. Vicente Méndez, 515, Chillán 3800062, Ñuble, Chile.
  • Ebel R; Centre for Biotechnology and Bioengineering (CeBiB), University of Chile, Beauchef 851, Santiago 8370459, Región Metropolitana, Chile.
  • Jaspars M; Centre for Biotechnology and Bioengineering (CeBiB), University of Chile, Beauchef 851, Santiago 8370459, Región Metropolitana, Chile.
Molecules ; 27(21)2022 Oct 24.
Article in En | MEDLINE | ID: mdl-36364011
ABSTRACT
Bacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a Saccharothrix sp. This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling. The compound was tested against the ESKAPE pathogens, where it showed activity against MRSA and five strains associated with bovine mastitis, where it showed activity against Enterococcus pseudoavium and Staphylycoccus Aureus subsp. Aureus.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Actinomycetales / Actinobacteria Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Actinomycetales / Actinobacteria Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country: