Physiological Roles of ß-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology.
Neurosci Bull
; 39(8): 1289-1308, 2023 Aug.
Article
in En
| MEDLINE
| ID: mdl-36443453
ABSTRACT
The physiological functions of endogenous amyloid-ß (Aß), which plays important role in the pathology of Alzheimer's disease (AD), have not been paid enough attention. Here, we review the multiple physiological effects of Aß, particularly in regulating synaptic transmission, and the possible mechanisms, in order to decipher the real characters of Aß under both physiological and pathological conditions. Some worthy studies have shown that the deprivation of endogenous Aß gives rise to synaptic dysfunction and cognitive deficiency, while the moderate elevation of this peptide enhances long term potentiation and leads to neuronal hyperexcitability. In this review, we provide a new view for understanding the role of Aß in AD pathophysiology from the perspective of physiological meaning.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alzheimer Disease
Limits:
Humans
Language:
En
Journal:
Neurosci Bull
Journal subject:
NEUROLOGIA
Year:
2023
Document type:
Article
Affiliation country: