Synthesis and antitumoral evaluation of natural product-like compounds based on tropolone and benzotropolone derivatives.
Arch Pharm (Weinheim)
; 356(3): e2200305, 2023 Mar.
Article
in En
| MEDLINE
| ID: mdl-36481876
ABSTRACT
We present the preparation of a series of novel natural product-like homobarrelenones, norcaranes, and dihydrofluorenones through a diversity-oriented synthetic (DOS) strategy that combines Diels-Alder reactions and phototransformations, as well as their biological evaluation against MCF-7, HT-29, and NCI-H460 human tumor cells. Six of these demonstrated activities in the micromolar range against the three cell lines, and none were predicted as cytotoxic against human nontumor cells according to in silico studies. In addition, within the set of active derivatives, three exhibited low unspecific cytotoxicity in a sperm motility assay. The rich functionality of the new compounds makes them ideal candidates for exhaustive structure-activity relationship studies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biflavonoids
/
Antineoplastic Agents
Limits:
Humans
/
Male
Language:
En
Journal:
Arch Pharm (Weinheim)
Year:
2023
Document type:
Article
Affiliation country: