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Human genetic diversity alters off-target outcomes of therapeutic gene editing.
Cancellieri, Samuele; Zeng, Jing; Lin, Linda Yingqi; Tognon, Manuel; Nguyen, My Anh; Lin, Jiecong; Bombieri, Nicola; Maitland, Stacy A; Ciuculescu, Marioara-Felicia; Katta, Varun; Tsai, Shengdar Q; Armant, Myriam; Wolfe, Scot A; Giugno, Rosalba; Bauer, Daniel E; Pinello, Luca.
Affiliation
  • Cancellieri S; Department of Computer Science, University of Verona, Verona, Italy.
  • Zeng J; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Lin LY; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Tognon M; Department of Computer Science, University of Verona, Verona, Italy.
  • Nguyen MA; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA, USA.
  • Lin J; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Bombieri N; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA, USA.
  • Maitland SA; Department of Computer Science, University of Verona, Verona, Italy.
  • Ciuculescu MF; Department of Molecular, Cell and Cancer Biology, Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Katta V; TransLab, Boston Children's Hospital, Boston, MA, USA.
  • Tsai SQ; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Armant M; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Wolfe SA; TransLab, Boston Children's Hospital, Boston, MA, USA.
  • Giugno R; Department of Molecular, Cell and Cancer Biology, Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Bauer DE; Department of Computer Science, University of Verona, Verona, Italy. rosalba.giugno@univr.it.
  • Pinello L; Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, MA, USA. bauer@bloodgroup.tch.harvard.edu.
Nat Genet ; 55(1): 34-43, 2023 Jan.
Article in En | MEDLINE | ID: mdl-36522432
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CRISPR-Cas Systems / Gene Editing Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CRISPR-Cas Systems / Gene Editing Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2023 Document type: Article Affiliation country: Country of publication: