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Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations.
Al-Karmalawy, Ahmed A; Nafie, Mohamed S; Shaldam, Moataz A; Elmaaty, Ayman Abo; Antar, Samar A; El-Hamaky, Anwar A; Saleh, Mohamed A; Elkamhawy, Ahmed; Tawfik, Haytham O.
Affiliation
  • Al-Karmalawy AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt.
  • Nafie MS; Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
  • Shaldam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
  • Elmaaty AA; Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt.
  • Antar SA; Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt.
  • El-Hamaky AA; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia 24016, United States.
  • Saleh MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.
  • Elkamhawy A; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, The United Arab Emirates.
  • Tawfik HO; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
J Med Chem ; 66(1): 777-792, 2023 01 12.
Article in En | MEDLINE | ID: mdl-36525642
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomerase / Antineoplastic Agents Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomerase / Antineoplastic Agents Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: Country of publication: