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A genetic off-target event in a site-specific integration cell line expressing monoclonal antibody has no impact on commercial suitability.
Tevelev, Barbara; Chambers, Andre; Ghosh, Swap; Zhang, Ying; Marzili, Lisa; Rouse, Jason C; Han, Shu; Moffat, Mark; Scarcelli, John J.
Affiliation
  • Tevelev B; Cell Line Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts, USA.
  • Chambers A; Cell Line Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri, USA.
  • Ghosh S; Cell Line Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri, USA.
  • Zhang Y; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts, USA.
  • Marzili L; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts, USA.
  • Rouse JC; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts, USA.
  • Han S; Cell Line Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts, USA.
  • Moffat M; Cell Line Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri, USA.
  • Scarcelli JJ; Cell Line Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts, USA.
Biotechnol Prog ; 39(2): e3320, 2023 03.
Article in En | MEDLINE | ID: mdl-36545889
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Monoclonal Limits: Animals Language: En Journal: Biotechnol Prog Journal subject: BIOTECNOLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Monoclonal Limits: Animals Language: En Journal: Biotechnol Prog Journal subject: BIOTECNOLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication: