Effect of extracts from several sponges of Yucatan Coast on Giardia lamblia and preliminary chemical investigation of the bioactive extract of Haliclona (Reinera) tubifera.
Nat Prod Res
; 37(23): 4023-4027, 2023.
Article
in En
| MEDLINE
| ID: mdl-36576083
ABSTRACT
In this study, twenty-four organic extracts from six marine sponge species, collected at shallows of Yucatan, Mexico, were evaluated against Giardia lamblia trophozoites and Vero cells. The dichloromethane and hexane extracts of Haliclona tubifera exhibited the highest antigiardiasic activity (IC50 = 1.00 and 2.11 µg/mL, respectively), as well as high selectivity (SI = 41.8 and > 47.4, respectively), while ethyl acetate and methanol extracts of Cinachyrella alloclada, and methanol extract of Suberites aurantiaca showed moderate activity. Contrastingly, the extracts of Halichondria magniculosa and Oceanapia nodosa were considered non actives. Consequently, the dichloromethane extract of H. tubifera were subject to an exploratory chemical study, isolating cholesterol, two benzaldehyde derivatives, three benzoic acid derivatives, cytosine, and thymine.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Giardia lamblia
/
Haliclona
Limits:
Animals
Country/Region as subject:
Mexico
Language:
En
Journal:
Nat Prod Res
Year:
2023
Document type:
Article
Affiliation country: