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Selective degradation of the p53-R175H oncogenic hotspot mutant by an RNA aptamer-based PROTAC.
Kong, Lingping; Meng, Fanlu; Wu, Sijin; Zhou, Ping; Ge, Ruixin; Liu, Min; Zhang, Linlin; Zhou, Jun; Zhong, Diansheng; Xie, Songbo.
Affiliation
  • Kong L; Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China.
  • Meng F; Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China.
  • Wu S; Laboratory of Molecular Modeling and Design, State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
  • Zhou P; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
  • Ge R; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
  • Liu M; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
  • Zhang L; Haihe Laboratory of Cell Ecosystem, Tianjin, China.
  • Zhou J; Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China.
  • Zhong D; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
  • Xie S; Haihe Laboratory of Cell Ecosystem, Tianjin, China.
Clin Transl Med ; 13(2): e1191, 2023 02.
Article in En | MEDLINE | ID: mdl-36710401

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Aptamers, Nucleotide Language: En Journal: Clin Transl Med Year: 2023 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Aptamers, Nucleotide Language: En Journal: Clin Transl Med Year: 2023 Document type: Article Affiliation country: Country of publication: