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A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.
Castelli, Lydia M; Lin, Ya-Hui; Sanchez-Martinez, Alvaro; Gül, Aytaç; Mohd Imran, Kamallia; Higginbottom, Adrian; Upadhyay, Santosh Kumar; Márkus, Nóra M; Rua Martins, Raquel; Cooper-Knock, Johnathan; Montmasson, Claire; Cohen, Rebecca; Walton, Amy; Bauer, Claudia S; De Vos, Kurt J; Mead, Richard J; Azzouz, Mimoun; Dominguez, Cyril; Ferraiuolo, Laura; Shaw, Pamela J; Whitworth, Alexander J; Hautbergue, Guillaume M.
Affiliation
  • Castelli LM; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Lin YH; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Sanchez-Martinez A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
  • Gül A; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Mohd Imran K; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Higginbottom A; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Upadhyay SK; Leicester Institute of Structural and Chemical Biology and Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK.
  • Márkus NM; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Rua Martins R; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Cooper-Knock J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Montmasson C; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Cohen R; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Walton A; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Bauer CS; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • De Vos KJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Mead RJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Azzouz M; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Dominguez C; Leicester Institute of Structural and Chemical Biology and Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK.
  • Ferraiuolo L; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
  • Whitworth AJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
  • Hautbergue GM; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK.
Sci Transl Med ; 15(685): eabo3823, 2023 03.
Article in En | MEDLINE | ID: mdl-36857431
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2023 Document type: Article Affiliation country: