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An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets.
Moskal, Natalia; Visanji, Naomi P; Gorbenko, Olena; Narasimhan, Vijay; Tyrrell, Hannah; Nash, Jess; Lewis, Peter N; McQuibban, G Angus.
Affiliation
  • Moskal N; Department of Biochemistry, University of Toronto, Toronto, Canada.
  • Visanji NP; Edmund J Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Canada.
  • Gorbenko O; Department of Biochemistry, University of Toronto, Toronto, Canada.
  • Narasimhan V; Zebrafish Centre for Advanced Drug Discovery and Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital and Department of Medicine and Physiology, University of Toronto, Toronto, Canada.
  • Tyrrell H; Department of Biochemistry, University of Toronto, Toronto, Canada.
  • Nash J; Department of Biochemistry, University of Toronto, Toronto, Canada.
  • Lewis PN; Department of Biochemistry, University of Toronto, Toronto, Canada.
  • McQuibban GA; Department of Biochemistry, University of Toronto, Toronto, Canada.
PLoS Biol ; 21(3): e3001977, 2023 03.
Article in En | MEDLINE | ID: mdl-36862640
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Probucol / Lipid Droplets Limits: Animals Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2023 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Probucol / Lipid Droplets Limits: Animals Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2023 Document type: Article Affiliation country: