Anti-Ri paraneoplastic neurological syndrome presenting with bilateral cranial nerve VI palsy and jaw dystonia-a distinctive syndrome within the anti-Ri spectrum? : Case report and literature review.
Wien Med Wochenschr
; 174(1-2): 16-21, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-36867318
ABSTRACT
OBJECTIVE:
Paraneoplastic neurological syndromes (PNS) are rare disorders associated with various onconeuronal antibodies. Anti-Ri antibodies (ANNA-2) are typically found in patients with opsoclonus myoclonus syndrome (OMS) and ataxia. CASE REPORT We present an anti-Ri antibody-positive 77-year-old woman with subacute progressive bilateral cranial nerve VI palsy, gait disturbance and jaw dystonia. MRI of the brain showed hyperintense signals on T2 bitemporal without contrast enhancement. Cerebrospinal fluid (CSF) examination exhibited mild pleocytosis of 13 cells/µl and positive oligoclonal bands. CSF was overall inconspicuous for a malignant or inflammatory etiology. Immunofluorescence analysis revealed anti-Ri antibodies in both serum and CSF. Subsequent diagnostic work up resulted in a newly diagnosed ductal carcinoma of the right breast. PNS in this case partially responded to the anti-tumor therapy.CONCLUSION:
This case shows similarities with recently published anti-Ri syndromes, which might form a distinct triad within the anti-Ri spectrum.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraneoplastic Syndromes
/
Paraneoplastic Syndromes, Nervous System
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Abducens Nerve Diseases
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Dystonia
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
Wien Med Wochenschr
Journal subject:
MEDICINA
Year:
2024
Document type:
Article
Affiliation country: