Three Novel Variants of t(8;21) and Classical t(8;21) Translocation in Acute Myeloid Leukemia.
Clin Lab
; 69(3)2023 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-36912302
ABSTRACT
BACKGROUND:
Some studies have discussed adverse prognosis factors of AML with t(8;21) to be closely related to genetic changes.METHOD:
We reviewed 58 cases of AML in children and adults with t(8;21)(q22;q22) translocation.RESULTS:
Five variant translocation cases were observed t(8;17;21)(q22;q12;q22) (case 1), t(1;8;21)(q12;q22;q22) (case 2), and t(8;12;21)(q22;p13;q22) (case 3). The translocations were first observed in three children. Case 2 was cured with chemotherapy, and the cut-off date of observation was 120 months. Case 3 relapsed after 1 year (overall survival [OS], 14 months). Patients with AML with t(8;21) variant translocation have different prognoses and require further study. Forty-two of the 58 cases were included in the survival analysis. Cox regression analysis showed that progression-free survival (PFS) was correlated with age group, white blood cell (WBC) count, bone marrow blast ratio, and loss of Y chromosome (-Y). Overall survival (OS) was correlated with age group, WBC count, and -Y. Childhood leukemia with t(8;21) has a better prognosis than adult leukemia. Survival curves were drawn according to age and cytogenetic abnormalities.CONCLUSIONS:
Progression-free survival was correlated with age, white blood cell (WBC) count, bone marrow blast ratio, and loss of Y chromosome (-Y). OS was correlated with age group, WBC count, and -Y chromosome. Child-hood leukemia with t(8;21) has a better prognosis than adult leukemia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, Myeloid, Acute
Type of study:
Prognostic_studies
Limits:
Adult
/
Child
/
Humans
Language:
En
Journal:
Clin Lab
Journal subject:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Year:
2023
Document type:
Article