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The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity.
Labrousse, Guillaume; Vande Perre, Pierre; Parra, Genis; Jaffrelot, Marion; Leroy, Laura; Chibon, Frederic; Escudie, Frederic; Selves, Janick; Hoffmann, Jean-Sebastien; Guimbaud, Rosine; Lutzmann, Malik.
Affiliation
  • Labrousse G; Cancer Research Center of Toulouse, CRCT, 2 Avenue Hubert Curien, 31000Toulouse, France.
  • Vande Perre P; Cancer Research Center of Toulouse, CRCT, 2 Avenue Hubert Curien, 31000Toulouse, France.
  • Parra G; Oncogenetics Department, Institute Claudius Regaud, IUCT-Oncopole, Toulouse, France.
  • Jaffrelot M; Center for Genomic Analysis, CNAG, Carrer de Baldiri Reixac 4, Barcelona, Spain.
  • Leroy L; Cancer Research Center of Toulouse, CRCT, 2 Avenue Hubert Curien, 31000Toulouse, France.
  • Chibon F; Oncogenetics Department, Institute Claudius Regaud, IUCT-Oncopole, Toulouse, France.
  • Escudie F; Department of Digestive Oncology, IUCT Rangueil-Larrey, CHU de Toulouse, Toulouse, France.
  • Selves J; Cancer Research Center of Toulouse, CRCT, 2 Avenue Hubert Curien, 31000Toulouse, France.
  • Hoffmann JS; Cancer Research Center of Toulouse, CRCT, 2 Avenue Hubert Curien, 31000Toulouse, France.
  • Guimbaud R; Laboratoire d'Excellence Toulouse Cancer (TOUCAN), Laboratoire de Pathologie, Institut Universitaire du Cancer-Toulouse, Oncopole, 1 Avenue Irene-Joliot-Curie, 31059Toulouse, France.
  • Lutzmann M; Cancer Research Center of Toulouse, CRCT, 2 Avenue Hubert Curien, 31000Toulouse, France.
NAR Cancer ; 5(2): zcad011, 2023 Jun.
Article in En | MEDLINE | ID: mdl-36915289
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NAR Cancer Year: 2023 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NAR Cancer Year: 2023 Document type: Article Affiliation country: Country of publication: