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Generation and characterization of iPS cell line (CTGUi001-A) from skin fibroblasts of a patient with Fabry disease.
Qin, Yu; Zhan, Jing-Qiong; Ma, Cui-Jiao; Cao, Chun-Yu; Zhang, Yuan; Min, Yuan-Ting; Lv, Ya-Feng.
Affiliation
  • Qin Y; The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang, Yichang 443000, Hubei, China.
  • Zhan JQ; The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang, Yichang 443000, Hubei, China.
  • Ma CJ; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Sciences, China Three Gorges University, Yichang 443002, Hubei, China.
  • Cao CY; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Sciences, China Three Gorges University, Yichang 443002, Hubei, China.
  • Zhang Y; Department of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address: zh.y.1989@163.com.
  • Min YT; Hubei Provincial Clinical Research Center for Precise Prevention and Treatment of Elderly Gastrointestinal Cancer, The Second People's Hospital of China Three Gorges University, Yichang 443002, Hubei, China. Electronic address: 674294473@qq.com.
  • Lv YF; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Sciences, China Three Gorges University, Yichang 443002, Hubei, China. Electronic address: lvyafeng@ctgu.edu.cn.
Stem Cell Res ; 69: 103063, 2023 06.
Article in En | MEDLINE | ID: mdl-36917862
We have generated an iPSCs line (CTGUi001-A) from dermal fibroblasts of a 16-year-old male Fabry disease patient with a novel GLA gene mutation (c.156C > A) using Sendai virus encoding the four Yamanaka factors OCT4, SOX2, KLF4, and c-MYC. The CTGUi001-A iPSC line displayed typical embryonic stem cell-like morphology, carried the GLA gene mutation, expressed several pluripotent stem cell makers, retained normal karyotype (46, XY) and was capable of forming teratomas containing three germ layers.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fabry Disease / Induced Pluripotent Stem Cells Limits: Adolescent / Humans / Male Language: En Journal: Stem Cell Res Year: 2023 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fabry Disease / Induced Pluripotent Stem Cells Limits: Adolescent / Humans / Male Language: En Journal: Stem Cell Res Year: 2023 Document type: Article Affiliation country: Country of publication: