Antibiotic associated diarrhea in outpatient pediatric antibiotic therapy.
BMC Pediatr
; 23(1): 121, 2023 03 18.
Article
in En
| MEDLINE
| ID: mdl-36932373
ABSTRACT
BACKGROUND:
Antibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region.METHODS:
The prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre.RESULTS:
A result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect.CONCLUSION:
This study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Outpatients
/
Anti-Bacterial Agents
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
Language:
En
Journal:
BMC Pediatr
Journal subject:
PEDIATRIA
Year:
2023
Document type:
Article
Affiliation country: