Your browser doesn't support javascript.
loading
Global epidemiology of HBV infection among hemodialysis patients: A systematic review and meta-analysis.
Khalesi, Zohreh; Razizadeh, Mohammad Hossein; Javadi, Mahsa; Bahavar, Atefeh; Keyvanlou, Zahra; Saadati, Hassan; Letafati, Arash; Khatami, Alireza; Kachooei, Atefeh; Khales, Pegah; Alborzi, Ehsan; Hosseini, Mahdiyeh; Tambrchi, Vahid; Jafari Maskouni, Elham; Taheri, Nafiseh; Zafarani, Alireza; Motlaghzadeh, Saeed; Dehghani, Hamid; Shalpoush, Nadia; Masoudi, Alireza; Noorafza, Marzieh; Habib, Zahra; Zarei, Mohammad; Kiani, Seyed Jalal; Ghorbani, Saied.
Affiliation
  • Khalesi Z; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Razizadeh MH; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Javadi M; Department of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Bahavar A; Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
  • Keyvanlou Z; Department of Virology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
  • Saadati H; Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran.
  • Letafati A; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Khatami A; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Kachooei A; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Khales P; Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Alborzi E; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Hosseini M; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Tambrchi V; Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
  • Jafari Maskouni E; Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Taheri N; Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Zafarani A; Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Motlaghzadeh S; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Dehghani H; Department of Biology, Jahrom Branch, Islamic Azad University, Fars, Iran.
  • Shalpoush N; Biology Cellular and Molecular Microbiology, Islamic Azad University of Medical Sciences, Tehran, Iran.
  • Masoudi A; Department of Laboratory Sciences, Faculty of Allied Medical Sciences, Medical University of Qom, Qom, Iran.
  • Noorafza M; Department of Microbiology, Faculty of Basic Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran.
  • Habib Z; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Zarei M; Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
  • Kiani SJ; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: kiani.j@iums.ac.ir.
  • Ghorbani S; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: Vet.S.Ghorbani@gmail.com.
Microb Pathog ; 179: 106080, 2023 Jun.
Article in En | MEDLINE | ID: mdl-36948364
ABSTRACT
BACKGROUND &

AIMS:

Hemodialysis (HD) is a life-saving procedure that purifies the blood in patients with end-stage renal disease (ESRD). Among all major complications, blood-borne diseases like hepatitis B virus (HBV) may be exposed as serious side effects of hemodialysis. A comprehensive review of the global burden of HBV among HD patients has not been written so far. The aim of the current systematic review and meta-analysis was to determine the globally epidemiology of HBV infection among HD patients.

METHODS:

Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, articles that investigated the prevalence of HBV among HD patients were searched from the major databases such as EMBASE, PubMed, Web of Science collection, and Scopus. Pooled prevalence with 95% CI and identification of heterogeneity were obtained using the random effects model and Cochran's Q-test, respectively, and quantification was evaluated using the I2 statistics. All statistical analyses were performed by STATA 14.1 statistical software.

RESULTS:

among 322 datasets (795,623 cases) that included in this study, the pooled prevalence of HBV infection among HD patients was 7.32% (95% CI 6.53-8.15%; I2 = 97.91%), including 7.57% (95% CI 6.69-8.48%) for HBsAg and 6.09% (95% CI 4.05-8.49%) for DNA, respectively. In addition, based on geographic area, the prevalence was 7.44% (95% CI 6.35-8.61%) in Asia, 4.32% (95% CI 2.21-7.04%) in North America, 7.07% (95% CI 6.35-8.61%) in Europe, 5.52% (95% CI 3.60-7.78%) in Africa, 8.45% (95% CI 5.81-11.78%) in Oceania, and 9.73% (95% CI 7.11-12.70%) in South America.

CONCLUSIONS:

Our analysis indicates a relatively high prevalence of HBV infection in HD patients, even in some developed countries. Considering that ESRD patients are not able to properly respond to the vaccination strategies in order to develop an acceptable immunity, vaccination of healthy individuals is highly recommended to arm their bodies for possible immunocompromise conditions in the future. Moreover, donated blood in blood transfusion centers should be checked for possible hepatitis B virus infection using sensitive molecular tests.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatitis B / Kidney Failure, Chronic Type of study: Prevalence_studies / Risk_factors_studies / Screening_studies / Systematic_reviews Limits: Humans Language: En Journal: Microb Pathog Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2023 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatitis B / Kidney Failure, Chronic Type of study: Prevalence_studies / Risk_factors_studies / Screening_studies / Systematic_reviews Limits: Humans Language: En Journal: Microb Pathog Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2023 Document type: Article Affiliation country:
...